2,4-Bis(fluoroalkyl)quinoline-3-carboxylates as Tools for the Development of Potential Agrochemical Ingredients Article - 2018

Fallia Aribi, Armen Panossian, Jean-Pierre Vors, Sergiy Pazenok, Frédéric Leroux

Fallia Aribi, Armen Panossian, Jean-Pierre Vors, Sergiy Pazenok, Frédéric Leroux, « 2,4-Bis(fluoroalkyl)quinoline-3-carboxylates as Tools for the Development of Potential Agrochemical Ingredients  », European Journal of Organic Chemistry, numéro spécial Organofluorine Chemistry in Europe, 2018, pp. 3792-3802. ISSN 1434-193X

Abstract

From an easy and scalable synthetic access to quinoline derivatives substituted by fluorinated groups in both C2-and C4-positions developed in our laboratory, we devised the synthesis of a new series of unprecedented 2,4-bis(fluoroalkyl)quinoline-3-carboxylates in two steps only. After standard saponification, the latter afforded their corresponding 2,4-bis(fluoroalkyl)quinoline-3-carboxylic acids, which served as pivotal intermediates for post-functionalization reactions. Indeed, the carboxylic function could then be derived according to known procedures and allowed the introduction of chemical diversity in C3-position of these unprecedented structures. The resulting highly functionalized quinolines will then serve as platform in the development of ingredients with strong potential for agrochemical research.

Voir la notice complète sur HAL

Actualités