Age, weight and decompression sickness in rats Article - Mars 2016

Peter Buzzacott, Michael Theron, Aleksandra Mazur, Qiong Wang, Kate Lambrechts, Ingrid Eftedal, Simin Berenji Ardestani, François Guerrero

Peter Buzzacott, Michael Theron, Aleksandra Mazur, Qiong Wang, Kate Lambrechts, Ingrid Eftedal, Simin Berenji Ardestani, François Guerrero, « Age, weight and decompression sickness in rats  », Archives of Physiology and Biochemistry, mars 2016, pp. 67 - 69. ISSN 1381-3455

Abstract

Objective : The aim of this study was to determine if, after controlling for weight, age is associated with decompression sickness (DCS) in rats. Methods : Following compression-decompression, male rats aged 11 weeks were observed for DCS. After two weeks recovery surviving rats were re-dived using the same compression-decompression profile. Results : In this experiment there was a clear difference between DCS outcome at ages 11 or 13 weeks in matched rats (p=0.002). Discussion : Even with weight included in the model age was significantly associated with DCS (p=0.01), yet after removal of weight the association was much stronger (p=0.002). Conclusion : We believe that age is likely to be found associated with the probability of DCS in a larger dataset with a wider range of parameters, after accounting for the effect of weight.

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