Effects of Totum-63 on glucose homeostasis and post-prandial glycemia : a translational study Article - 2021

Vivien Chavanelle, Yolanda Otero, Florian Le Joubioux, Doriane Ripoche, Maxime Bargetto, Aurore Vluggens, Christophe Montaurier, Gisele Pickering, Gilles Ducheix, Claude Dubray, Christian Dualé, Sylvia Boulliau, Nicolas Macian, Geoffroy Marceau, Vincent Sapin, Frédéric Dutheil, Bruno Guigas, Thierry Maugard, Nathalie Boisseau, Murielle Cazaubiel, Sébastien Peltier, Pascal Sirvent

Vivien Chavanelle, Yolanda Otero, Florian Le Joubioux, Doriane Ripoche, Maxime Bargetto, Aurore Vluggens, Christophe Montaurier, Gisele Pickering, Gilles Ducheix, Claude Dubray, Christian Dualé, Sylvia Boulliau, Nicolas Macian, Geoffroy Marceau, Vincent Sapin, Frédéric Dutheil, Bruno Guigas, Thierry Maugard, Nathalie Boisseau, Murielle Cazaubiel, Sébastien Peltier, Pascal Sirvent, « Effects of Totum-63 on glucose homeostasis and post-prandial glycemia : a translational study  », AJP - Endocrinology and Metabolism, 2021, E1119-E1137. ISSN 0193-1849

Abstract

Global prevalence of type 2 diabetes (T2D) is rising and may affect 700 million people by 2045. Totum-63 is a polyphenol-rich natural composition developed to reduce the risk of T2D. We first investigated the effects of Totum-63 supplementation in high-fat diet (HFD)-fed mice for up to 16 weeks, and thereafter assessed its safety and efficacy (2.5 g or 5 g per day) in 14 overweight men (mean age 51.5 years, BMI 27.6 kg.m -2 ) for 4 weeks. In HFD-fed mice, Totum-63 reduced body weight and fat mass gain while lean mass was unchanged. Moreover, fecal energy excretion was higher in Totum-63 supplemented mice, suggesting a reduction of calorie absorption in the digestive tract. In the gut, metagenomic analyses of fecal microbiota revealed a partial restoration of HFD-induced microbial imbalance, as shown by PCoA analysis of microbiota composition. HFD-induced increase in HOMA-IR score was delayed in supplemented mice, and insulin response to an OGTT was significantly reduced, suggesting that Totum-63 may prevent HFD-related impairments in glucose homeostasis. Interestingly, these improvements could be linked to restored insulin signaling in subcutaneous adipose tissue and soleus muscle. In the liver, HFD-induced steatosis was reduced by 40% (as shown by triglyceride content). In the subsequent study in men, Totum-63 (5g.day -1 ) improved glucose and insulin responses to a high-carbohydrate breakfast test (84% kcal carbohydrates). It was well tolerated, with no clinically significant adverse events reported. Collectively, these data suggest that Totum-63 could improve glucose homeostasis in both HFD-fed mice and overweight individuals, presumably through a multi-targeted action on different metabolic organs.

Voir la notice complète sur HAL

Actualités