Exploring functional genomics for drug target and therapeutics discovery in Plasmodia. Article - Février 2008

L. Birkholtz, A. C. van Brummelen, K. Clark, J. Niemand, E. Maréchal, M. Llinás, A. I. Louw

L. Birkholtz, A. C. van Brummelen, K. Clark, J. Niemand, E. Maréchal, M. Llinás, A. I. Louw, « Exploring functional genomics for drug target and therapeutics discovery in Plasmodia.  », Acta Tropica, février 2008, pp. 113-23. ISSN 0001-706X

Abstract

Functional genomics approaches are indispensable tools in the drug discovery arena and have recently attained increased attention in antibacterial drug discovery research. However, the application of functional genomics to post-genomics research of Plasmodia is still in comparatively early stages. Nonetheless, with this genus having the most species sequenced of any eukaryotic organism so far, the Plasmodia could provide unique opportunities for the study of intracellular eukaryotic pathogens. This review presents the status quo of functional genomics of the malaria parasite including descriptions of the transcriptome, proteome and interactome. We provide examples for the in silico mining of the X-ome data sets and illustrate how X-omic data from drug challenged parasites might be used in elucidating amongst others, the mode-of-action of inhibitory compounds, validate potential targets and discover novel targets/therapeutics.

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