Human cryptosporidiosis in immunodeficient patients in France (2015–2017) Article - Septembre 2018

Damien Costa, Romy Razakandrainibe, Marc Sautour, Stéphane Valot, Louise Basmaciyan, Gilles Gargala, Loïc Favennec, Frédéric Dalle, Anne Debourgogne, Adela Angoulvant, Patrice Agnamey, Julie Bonhomme, Brigitte Degeilh, Cathy Chemla, Cécile Garnaud, Coralie Lollivier, Cécile Angebault, Pascal Delaunay, Guillaume Desoubeaux, Emilie Frealle, Frédéric Grenouillet, Florent Morio, Françoise Botterel, Ghania Belkadi, Hélène Yera, Gilles Nevez, Xavier Iriart, Isabelle Accoceberry, Julie Brunet, Marc Thellier, Denis Lemeteil, Meja Rabodonirina, Milène Sasso, Charline Miossec, Murielle Nicolas, Nicole Desbois, Philippe Poirier, Christelle Pomares, Sandrine Houzé, Yohann Le Govic, Anne Pauline Bellanger, Franck Labbe, Marie Laure Dardé, Olivier Duquesnoy, Pierre Flori, Patrick Bastien, Thomas Gueudet, Isabelle Villena, Dominique Aubert, Estelle Cateau, Marie-Elisabeth Bougnoux, Nathalie Kapel, Eric Dannaoui, Alexis Valentin, Anne Totet, Jean Menotti, Denis Blanchet, Magalie Demar, Emmanuel Dutoit, Renaud Piarroux, Emilie Sitterlé, Denis Magne, Samsa Hamane, Antoine Berry, Cecile Ramade

Damien Costa, Romy Razakandrainibe, Marc Sautour, Stéphane Valot, Louise Basmaciyan, Gilles Gargala, Loïc Favennec, Frédéric Dalle, Anne Debourgogne, Adela Angoulvant, Patrice Agnamey, Julie Bonhomme, Brigitte Degeilh, Cathy Chemla, Cécile Garnaud, Coralie Lollivier, Cécile Angebault, Pascal Delaunay, Guillaume Desoubeaux, Emilie Frealle, Frédéric Grenouillet, Florent Morio, Françoise Botterel, Ghania Belkadi, Hélène Yera, Gilles Nevez, Xavier Iriart, Isabelle Accoceberry, Julie Brunet, Marc Thellier, Denis Lemeteil, Meja Rabodonirina, Milène Sasso, Charline Miossec, Murielle Nicolas, Nicole Desbois, Philippe Poirier, Christelle Pomares, Sandrine Houzé, Yohann Le Govic, Anne Pauline Bellanger, Franck Labbe, Marie Laure Dardé, Olivier Duquesnoy, Pierre Flori, Patrick Bastien, Thomas Gueudet, Isabelle Villena, Dominique Aubert, Estelle Cateau, Marie-Elisabeth Bougnoux, Nathalie Kapel, Eric Dannaoui, Alexis Valentin, Anne Totet, Jean Menotti, Denis Blanchet, Magalie Demar, Emmanuel Dutoit, Renaud Piarroux, Emilie Sitterlé, Denis Magne, Samsa Hamane, Antoine Berry, Cecile Ramade, « Human cryptosporidiosis in immunodeficient patients in France (2015–2017)  », Experimental Parasitology, septembre 2018, pp. 108-112. ISSN 0014-4894

Abstract

Cryptosporidiosis is a common disease in children and immunodeficient individuals. In 2006, a national network was set up on the surveillance of human cryptosporidiosis in France. Since January 2015, the 41 tertiary care hospitals and the 3 private laboratories of the French National Network on the surveillance of human cryptosporidiosis have been able to declare confirmed cases of cryptosporidiosis online. Between 2015 and 2017, 210 cases of cryptosporidiosis were declared in immunodeficient patients in France ; Cryptosporidium parvum and Cryptosporidium hominis represented 66% and 22% of cases, respectively. A peak was observed in autumn. Cryptosporidiosis occurred mainly in a context of solid organ transplantation (SOT) (49%) and of HIV infection (30%). In SOT recipients, cryptosporidiosis appeared more frequently in the first 6 months post transplantation. Regarding cases declared in SOT recipients, mycophenolate mofetil was used in 68%. A mortality rate of 6% was observed. Present results underline the importance of screening for cryptosporidiosis in immunocompromised patients suffering from diarrhea, especially in the course of major cell mediated immunodeficiency or even systematic screening before SOT. Exclusive Cryptosporidium free water feeding could be suggested during major cell mediated immunodeficiency.

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