Interplay among distinct Ca 2+ conductances drives Ca 2+ sparks/spontaneous transient outward currents in rat cerebral arteries Article - Février 2017

Ahmed Hashad, Neil Mazumdar, Monica Romero, Anders Nygren, Kamran Bigdely-Shamloo, Osama Harraz, Jose Puglisi, Edward Vigmond, Sean Wilson, Donald Welsh

Ahmed Hashad, Neil Mazumdar, Monica Romero, Anders Nygren, Kamran Bigdely-Shamloo, Osama Harraz, Jose Puglisi, Edward Vigmond, Sean Wilson, Donald Welsh, « Interplay among distinct Ca 2+ conductances drives Ca 2+ sparks/spontaneous transient outward currents in rat cerebral arteries  », The Journal of Physiology, février 2017, pp. 1111-1126. ISSN 0022-3751

Abstract

Distinct Ca2+ channels work in a coordinated manner to grade Ca2+ spark/spontaneous transient outward currents (STOCs) in rat cerebral arteries. The relative contribution of each Ca2+ channel to Ca2+ spark/STOC production depends upon their biophysical properties and the resting membrane potential of smooth muscle. Na+ /Ca2+ exchanger, but not TRP channels, can also facilitate STOC production.

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