Reduction of death receptor 5 expression and apoptosis of CD4+ T cells from HIV controllers Article - Novembre 2014

Lucie Barblu, Nikaïa Smith, Stéphanie Durand, Daniel Scott-Algara, Faroudy Boufassa, Jean-François Delfraissy, Andrea Cimarelli, Olivier Lambotte, Jean-Philippe Herbeuval

Lucie Barblu, Nikaïa Smith, Stéphanie Durand, Daniel Scott-Algara, Faroudy Boufassa, Jean-François Delfraissy, Andrea Cimarelli, Olivier Lambotte, Jean-Philippe Herbeuval, « Reduction of death receptor 5 expression and apoptosis of CD4+ T cells from HIV controllers  », Clinical Immunology, novembre 2014, pp. 17-26. ISSN 1521-6616

Abstract

TNF-related apoptosis ligand (TRAIL) induces apoptosis of HIV-1-exposed CD4 T cells expressing the death receptor 5 (DR5) in vitro and has been associated with reduced CD4 T cell number in viremic HIV-1-infected patients. Alterations of the TRAIL/DR5 apoptotic pathway could be involved in the absence of massive CD4 T cell depletion in HIV-1-infected controllers (HIC). We studied here apoptosis of CD4 T cells from HIV-infected progressors and controllers. Reduced apoptosis of CD4 T cells from HIC was observed upon HIV stimulation. This lower apoptosis correlated with a deficiency of DR5 cell surface expression by CD4 T cells upon HIV-1 stimulation. The significant lower apoptosis observed in CD4 T cells after HIV exposure, associated with lower expression of membrane DR5 could explain the better survival of HIV-specific CD4 T cells from HIV controllers. The levels of DR5 cell surface expression on CD4 T cells could represent a new prognostic marker.

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