Simalikalactone D is responsible for the antimalarial properties of an Amazonian traditional remedy made with Quassia amara L. (Simaroubaceae) Article - Avril 2007

Stephane Bertani, Emeline Houel, Didier Stien, Lionel Chevolot, Valérie Jullian, Giovanni Garavito, Genevieve Bourdy, Eric Deharo

Stephane Bertani, Emeline Houel, Didier Stien, Lionel Chevolot, Valérie Jullian, Giovanni Garavito, Genevieve Bourdy, Eric Deharo, « Simalikalactone D is responsible for the antimalarial properties of an Amazonian traditional remedy made with Quassia amara L. (Simaroubaceae)  », Journal of Ethnopharmacology, avril 2007, pp. 155-157. ISSN 0378-8741

Abstract

French Guiana (North-East Amazonia) records high malaria incidence rates. The traditional antimalarial remedy most widespread there is a simple tea made out from Quassia amara L. leaves (Simaroubaceae). This herbal tea displays an excellent antimalarial activity both in vitro and in vivo. A known quassinoid, simalikalactone D (SkD), was identified as the active compound, with an IC50 value of 10nM against FcB1 Plasmodium falciparum chloroquine resistant strain in vitro. Lastly, it inhibits 50% of Plasmodium yoelii yoelii rodent malaria parasite at 3.7 mg/kg/day in vivo by oral route. These findings confirm the traditional use of this herbal tea.

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