Synthesis and Biological Evaluation of Four New Ricinoleic Acid-Derived 1-O-alkylglycerols Article - 2020

René Pemha, Victor Kuete, Jean-Marie Pagès, Dieudonné Emmanuel Pegnyemb, Paul Mosset

René Pemha, Victor Kuete, Jean-Marie Pagès, Dieudonné Emmanuel Pegnyemb, Paul Mosset, « Synthesis and Biological Evaluation of Four New Ricinoleic Acid-Derived 1-O-alkylglycerols  », Marine drugs, 2020. ISSN 1660-3397

Abstract

A series of novel substituted 1—alkylglycerols (AKGs) containing methoxy (), -difluoro (), azide () and hydroxy () group at 12 position in the alkyl chain were synthesized from commercially available ricinoleic acid (). The structures of these new synthesized AKGs were established by NMR experiments as well as from the HRMS and elementary analysis data. The antimicrobial activities of the studied AKGs - were evaluated, respectively, and all compounds exhibited antimicrobial activity to different extents alone and also when combined with some commonly used antibiotics (gentamicin, tetracycline, ciprofloxacin and ampicillin). AKG was viewed as a lead compound for this series as it exhibited significantly higher antimicrobial activity than compounds -.

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