Temporal evolution of mechanical properties of skeletal tissue regeneration in rabbits : an experimental study Article - Octobre 2007

Didier Moukoko, Martine Pithioux, Patrick Chabrand

Didier Moukoko, Martine Pithioux, Patrick Chabrand, « Temporal evolution of mechanical properties of skeletal tissue regeneration in rabbits : an experimental study  », Medical and Biological Engineering and Computing, octobre 2007, pp. 989-995. ISSN 0140-0118

Abstract

Various mathematical models represent the effects of local mechanical environment on the regulation of skeletal regeneration. Their relevance relies on an accurate description of the evolving mechanical properties of the regenerating tissue. The object of this study was to develop an experimental model which made it possible to characterize the temporal evolution of the structural and mechanical properties during unloaded enchondral osteogenesis in the New Zealand rabbit, a standard animal model for studies of osteogenesis and chondrogenesis. A 25 mm segment of tibial diaphysis was removed sub-periosteally from rabbits. The defect was repaired by the preserved periosteum. An external fixator was applied to prevent mechanical loading during osteogenesis. The regenerated skeletal tissues were studied by CT scan, histology and mechanical tests. The traction tests between 7 and 21 days post-surgery were done on formaldehyde-fixated tissue allowing to obtain force/displacement curves. The viscoelastic properties of the regenerating skeletal tissues were visualized throughout the repair process.

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