The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome Article - Juillet 2006

Mohammed Sebaihia, Brendan Wren, Peter Mullany, Neil Fairweather, Nigel Minton, Richard Stabler, Nicholas Thomson, Adam Roberts, Ana Cerdeño-Tárraga, Hongmei Wang, Matthew Tg Holden, Anne Wright, Carol Churcher, Michael Quail, Stephen Baker, Nathalie Bason, Karen Brooks, Tracey Chillingworth, Ann Cronin, Paul Davis, Linda Dowd, Audrey Fraser, Theresa Feltwell, Zahra Hance, Simon Holroyd, Kay Jagels, Sharon Moule, Karen Mungall, Claire Price, Ester Rabbinowitsch, Sarah Sharp, Mark Simmonds, Kim Stevens, Louise Unwin, Sally Whithead, Bruno Dupuy, Gordon Dougan, Bart Barrell, Julian Parkhill

Mohammed Sebaihia, Brendan Wren, Peter Mullany, Neil Fairweather, Nigel Minton, Richard Stabler, Nicholas Thomson, Adam Roberts, Ana Cerdeño-Tárraga, Hongmei Wang, Matthew Tg Holden, Anne Wright, Carol Churcher, Michael Quail, Stephen Baker, Nathalie Bason, Karen Brooks, Tracey Chillingworth, Ann Cronin, Paul Davis, Linda Dowd, Audrey Fraser, Theresa Feltwell, Zahra Hance, Simon Holroyd, Kay Jagels, Sharon Moule, Karen Mungall, Claire Price, Ester Rabbinowitsch, Sarah Sharp, Mark Simmonds, Kim Stevens, Louise Unwin, Sally Whithead, Bruno Dupuy, Gordon Dougan, Bart Barrell, Julian Parkhill, « The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome  », Nature Genetics, juillet 2006, pp. 779-786. ISSN 1061-4036

Abstract

We determined the complete genome sequence of Clostridium difficile strain 630, a virulent and multidrug-resistant strain. Our analysis indicates that a large proportion (11%) of the genome consists of mobile genetic elements, mainly in the form of conjugative transposons. These mobile elements are putatively responsible for the acquisition by C. difficile of an extensive array of genes involved in antimicrobial resistance, virulence, host interaction and the production of surface structures. The metabolic capabilities encoded in the genome show multiple adaptations for survival and growth within the gut environment. The extreme genome variability was confirmed by whole-genome microarray analysis ; it may reflect the organism’s niche in the gut and should provide information on the evolution of virulence in this organism.

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