The role of the capping bond effect on pyclen Y-nat(3+)/Y-90(3+) chelates : full control of the regiospecific N-functionalization makes the difference Article - Octobre 2017

Mariane Le Fur, Maryline Beyler, Eniko Molnar, Olivier Fougere, David Esteban-Gomez, Gyula Tircso, Carlos Platas-Iglesias, Nicolas Lepareur, Olivier Rousseaux, Raphaël Tripier

Mariane Le Fur, Maryline Beyler, Eniko Molnar, Olivier Fougere, David Esteban-Gomez, Gyula Tircso, Carlos Platas-Iglesias, Nicolas Lepareur, Olivier Rousseaux, Raphaël Tripier, « The role of the capping bond effect on pyclen Y-nat(3+)/Y-90(3+) chelates : full control of the regiospecific N-functionalization makes the difference  », Chemical Communications, octobre 2017, pp. 9534-9537. ISSN 1359-7345

Abstract

Thanks to a smart regiospecific N-functionalization, a pyclen based ligand bearing one picolinate and two acetate arms organized in a dissymmetric manner was synthesized for Y3+ complexation, and compared to its symmetric analogue. The nature of the capping bonds around the metal coordination environment has a dramatic effect on the properties of the chelate, the Y-nat(3+) and Y-90(3+) dissymmetric derivatives presenting enhanced thermodynamic stability and kinetic inertness.

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